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Meanings of NRTI in English
An antiviral drug used against HIV; is incorporated into the DNA of the virus and stops the building process; results in incomplete DNA that cannot create a new virus; often used in combination with other drugs.
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Examples for "nucleoside reverse transcriptase inhibitor"
Examples for "nucleoside reverse transcriptase inhibitor"
1
Patients received 3 different backbones of nucleoside reverse transcriptase inhibitor in a nonrandomized manner.
2
Mitochondrial toxicity has been implicated in the development of a variety of nucleoside reverse transcriptase inhibitor-associated syndromes.
3
Dolutegravir compares favourably in efficacy and safety to a boosted darunavir regimen with nucleoside reverse transcriptase inhibitor background treatment for HIV-1-infected treatment-naive patients.
4
Survival methods (Kaplan-Meier, Cox proportional hazard) assessed factors associated with regimen durability including an interaction term between nucleoside reverse transcriptase inhibitor backbone and time.
5
We evaluated plasma levels of F2-isoprostanes-the most accurate method to measure oxidant stress in vivo-in a group of 59 nucleoside reverse transcriptase inhibitor-treated HIV-1-infected subjects.
Usage of NRTI in English
1
The only factor associated with mtDNA depletion was duration of NRTI use.
2
Two children had baseline NRTI and PI mutations, suggesting previous maternal ART.
3
Morbidity and mortality were not changed by the addition of dual NRTI therapy.
4
Differences in drug-resistance patterns in both NRTI and NNRTI were observed by site.
5
We explored the relationships between oxidant stress and NRTI-induced peripheral neuropathy.
6
We assessed the safety and activity of regimens that did not include an NRTI.
7
Twelve of the 18 patients modified their NRTI regimen at the time ritonavir-saquinavir was initiated.
8
Forty-one per cent of patients discontinued their NRTI-sparing regimen.
9
An in vitro assay to predict mitochondrial toxicity of in-use and developmental NRTI would be invaluable.
10
These compounds are effective against many NRTI drug-resistant RT variants; however, the M184V mutant is relatively resistant.
11
Maximal power output was diminished and anaerobic threshold occurred earlier in HIV-infected patients, regardless of NRTI exposure.
12
Here, analysing a large database, we report the selection of another rare K65E mutation in patients failing on NRTI-containing regimens.
13
The in vitro assay described here might be used to predict the mitochondrial toxicity of other NRTI, alone or in combination.
14
More extensive studies of mtDNA mutation at the single molecule level are required to correlate mitochondrial dysfunction with NRTI-caused molecular defects in mtDNA.
15
All laboratories measured protease inhibitors, most measured at least 1 non-nucleoside reverse transcription inhibitor and 5 had NRTI capabilities.
16
These results indicate that NRTIs impair endothelium-dependent relaxation by increasing superoxide levels and suggest that NRTI therapy contributes to cardiovascular complications in acquired immunodeficiency syndrome.
About this term
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NRTI through the time